Adam (Joseph Gordon-Levitt) must undergo surgery to remove his spinal tumor after the chemotherapy fails to abate the tumor's growth. The surgery is successful and Adam is cancer-free.
The movie ends with his therapist Katherine (Anna Kendrick) bringing pizza over to his house as it is implied they are starting a relationship.
Kyle (Seth Rogen) is with Adam every step of the way as he helps Adam shave his head, kick out his unfaithful girlfriend Rachael (Bryce Dallas Howard), gets him laid by a pick-up in a bar, smokes his medicinal marijuana with him and bandages his scar.
Adam's fellow chemo patient Mitch (Matt Frewer) dies.
We do not know Alan's (Phillip Baker Hall) fate.
Thanks Evil Ed!