The Out of Towners
(1970)

After a night in which everything possible went wrong,George (Jack Lemmon) and Gwen (Sandy Dennis) Kellerman get back to the Waldorf Astoria Hotel, where their room is ready.

There's no time to get a hot meal, since George's job interview is coming up soon, so George grabs an apple from the fruit basket the hotel has provided... and immediately loses a tooth.

A dirty, unshaved George makes it to his interview on time, and does well. He comes back to the hotel and tells Gwen that he was offered a great job with a huge salary. Gwen replies that New York City is a horrible place, and that she hopes George turned down the job. And he did turn down the job. They both agree to return to a quieter life in their home town of Twin Oaks, Ohio.

But their misadventures aren't over yet- as they're flying back home, the plane is hijacked! 

Thanks John L!