This is an homage to Cannibal horror/gore movies of the 70s and 80s, and its plot actually shares a lot with that of "Cannibal ferox", sequel to the notorious "Cannibal Holocaust".
Everyone, except for Justine (Lorenza Izzy) and Alejandro (Ariel Levy), dies; Alejandro's fate, however, is left somewhat ambiguous.
After an explosion sends their plane crashing onto the middle of the jungle, the members of the group start dying, one after the other, in various circumstances; mostly, at the hands of the cannibal tribe they were vouching for with their protest in the first place:
- A couple of them get tossed off the plane, and killed, during the accident.
- Carlos (Matias Lopez) dies upon crash-landing, when a log goes through the cabin and mangles his head.
- Kara (Ignacia Allamand) is speared through her neck and head when tribesmen come upon the crash site and attack the group while Daniel (Nicolas Martinez) tries to use the GPS phone to call for help.
- Jonah (Aaron Burns) has his eyes and tongue crudely cut off of him; then, he gets dismembered and beheaded before a cheering village, and to the horror of the rest of the group; and, finally, his torso and members are cooked in an oven and consumed by the cannibals.
- Samantha (Magda Apanowicz) is killed off-screen, after a test performed on her, Justine and Amy (Kirby Bliss Blanton), by the Female Elder, to see if they were virgins -apparently, only Samantha wasn't-. The next day, the jailed group is fed pork scraps that Amy comes to discover also contain Samantha's remains when she finishes her ration and sees a piece of Samantha's tattooed skin in the bottom of the bowl.
- Amy commits suicide when, upon discovering Samantha's skin in her food, she smashes the bowl and slits her throat with one of the shards. Then, Lars (Daryl Sabara) has the idea of stuffing the pack of marijuana Carlos gave him earlier, down her throat, with the hopes of poisoning the villagers if they cook and eat her -which they do, but it only gets them VERY, VERY HIGH-.
- While Justine, Daniel and Lars try to escape, Alejandro cowardly uses a dart against Lars, forcing him to stay behind. As a punishment, the villagers pull Lars out of the cage and, when he wakes up, is attacked and eaten alive by the villagers.
- Justine and Daniel get recaptured; Justine is prepared for a genital mutilation ritual, while Daniel is tied to a pole, has his limbs broken, is smeared with a green powder and fed to ants. A distraction in the jungle allows Justine to break free; before escaping, she finds Daniel, who begs her to kill him (he's been left in bad shape due to the ant attack); the young village girl who helped her knocks him unconscious with the white numbing powder and slits his throat.
Eventually, Justine is found (and almost killed) by militia fighting off the villagers, and taken to safety. She makes it back to New York and lies about the whole experience, alluding that she was the sole survivor of the crash and, thanks to the villagers, she was able to return safe and sound. In the end, she despondently notices more people doing activism on campus, while wearing T-shirts with Alejandro's face on it, as if he were some sort of a martyr, when, in reality, he was playing everyone all along, for his own selfish purposes.
A mid-credits scene shows a phone conversation between Justine and a sister of Alejandro, while a zooming satellite image shows Alejandro, covered in black, standing in the middle of the jungle. It is not made clear whether he had become the tribe's new henchman (like the bald, yellow-head hunter from before) or if he was doomed to die at their hands.