Requiem for a Dream
Sara Goldfarb (Ellen Burstyn) flips out and is admitted to a hospital where she undergoes electroshock therapy. Harry Goldfarb (Jared Leto) gets his arm amputated, and is not expected to survive. Marion Silver (Jennifer Connelly) starts whoring herself for drugs. Tyrone C. Love (Marlon Wayans) goes to prison.
Thanks, Anna P, Kim A, Tuxxer, Per L and Robert R!