Twisted

John Mills (Samuel L. Jackson) is the killer. He used Rohypnol (ruffies) to knock out Jessica Shepard (Ashley Judd) night after night, leading her to believe that she was the killer. When Mills and Shepard go to investigate Shepard's partner Mike Delmarco (Andy Garcia), the truth comes out. Before Mills can kill Delmarco, Shepard shoots and kills Mills.
Thanks, Marc S!

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