CODE 11-14
(2003)

The serial killer is first class flight attendant "Justin" (Stephen Lang). (This is the one who sits next to the son while his mom is away)

FBI Agent Kurt Novak (David James Elliot) and his wife Michelle (Terry Farrell) are able to subdue him in the cargo deck. Their son (Myles Jeffrey) saves the plane by retrieving the computer input unit from the killer and returning it to the pilot, who is able to restart the computer.

Thanks Tilman!

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Read more about this film at The Internet Movie Database.