Wes Cravens's CURSED
Jake (Joshua Jackson) is the original werewolf. He had sex with Joanie and turned Joanie into a werewolf and she was the one killing all the young women around L.A so that Jake wouldn't sleep with them.
Joanie is killed by the police in Jake's club and then Jake is killed by Ellie (Christina Ricci) and Jimmy after he shows up at their house and they stab him in the heart with a silver spatula.
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Read more about this film at The Internet Movie Database.