The experimental drug treatment is successful, and George Simmons (Adam Sandler) beats leukemia.
However, he fails to win back his old love, Laura (Leslie Mann), who elects to stay with her husband and daughters. George blames Ira for ruining his chances with Laura, and fires him.
Ira (Seth Rogen) goes back to work at the delicatessen, begins to date Daisy, and shows improvement as a standup comedian.
George visits Ira at the deli, and offers some ideas for new jokes. Ira accepts gratefully, and they begin working out a new routine for Ira. Nothing is resolved, but it appears George has mellowed a bit, Ira has matured a bit, and they may yet become real friends.
Thanks John L!