Mr. Fox (voiced by George Clooney) moves his family to a new tree house directly across from the farms of Boggis, Bunce and Bean. A retired animal snatcher, Mr. Fox's thirst for adventure drives him to break into each of the three farms and steal livestock and cider along with his impressionable sidekick, Kylie, and nephew Kristofferson. Mrs. Fox (voiced by Meryl Streep) realizes what is going on too late and the farmers declare war on the Foxes.
In an attempt to exterminate the Foxes, the farmers actually destroy the homes of all the neighboring animals. Kristofferson is kidnapped by Farmer Bean and Mr. Fox rallies all the neighbors to help get his nephew back and defeat the farmers for good. Mr. Fox, his son Ash (voiced by Jason Schwartzman), and Kylie rescue Kristofferson and outwit the farmers. But with their homes destroyed, all of the animals are forced to move into an underground sewer system and start over. With food scare, Mr. Fox tunnels his way into a Boggis, Bunce and Bean grocery store where all the animals can get food from. Mrs. Fox tells her husband that she is pregnant again, Mr. Fox proudly wears his tail pinned on (it was shot off by Bean in their initial fight) and he ends with a toast to his family and friends.